Combination pill for schizophrenia symptoms
Treatments studied
Part of Mental health clinical trials.
This study tests a new combination pill (olanzapine and samidorphan) for adults with schizophrenia. It aims to see if the combination helps control symptoms while potentially reducing weight gain, which is a common side effect of olanzapine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 55 years old.
- Your weight must be in a healthy range, with a body mass index (BMI) between 18 and 30.
- You must have a primary diagnosis of schizophrenia.
- You cannot have other major mental health conditions like schizoaffective disorder, bipolar disorder, or current depression.
- You cannot have diabetes or a history of diabetes.
- You cannot have taken certain antipsychotic medications (olanzapine, clozapine, chlorpromazine, thioridazine) in the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 3 study tests a treatment aimed at reducing unhealthy weight gain in teens with schizophrenia or bipolar I disorder, using changes in BMI (a height-and-weight measure). It may help families who are concerned about weight changes that can happen with some psychiatric medicines.
This trial tests a slower, lower-dose schedule of the drug olanzapine for people with schizophrenia. It aims to see if a gentler start is safer and works as well, especially for those who may need less medication due to other health conditions.
This study tests a new combination medication (xanomeline/trospium) for people with early schizophrenia who want to switch antipsychotics. The goal is to see if it helps control symptoms and is easier to tolerate.
This study tests whether a combination of a daily medication (olanzapine-samidorphan) and a structured exercise program can help people with schizophrenia, schizoaffective disorder, or bipolar disorder improve their health and well-being.
This trial tests if the drug olanzapine can help improve appetite in people with head and neck cancer who are getting chemotherapy and radiation. It aims to prevent or reduce weight loss during treatment.
This Phase 2 trial tests whether olanzapine can help people with advanced cancer who are losing weight and not eating enough. It looks for improvements in appetite and weight while you receive your first-line palliative cancer treatment.
Hear when a new Schizophrenia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.