Study of a new schizophrenia medication tablets
Treatments studied
Part of Mental health clinical trials.
This trial tests a new combination tablet (olanzapine-samidorphan) for adults with schizophrenia. It aims to see if it helps control symptoms while potentially reducing weight gain, which can be a side effect of some schizophrenia medicines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 55 years old.
- Your body mass index (BMI) is between 18 and 30 (this is a measure of weight relative to height).
- You have been diagnosed with schizophrenia by a doctor.
- Your schizophrenia symptoms are at least moderately severe (measured by a standard rating scale).
- You have not taken certain antipsychotic medicines (olanzapine, clozapine, chlorpromazine, thioridazine) in the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 3 study tests a treatment aimed at reducing unhealthy weight gain in teens with schizophrenia or bipolar I disorder, using changes in BMI (a height-and-weight measure). It may help families who are concerned about weight changes that can happen with some psychiatric medicines.
This trial tests a slower, lower-dose schedule of the drug olanzapine for people with schizophrenia. It aims to see if a gentler start is safer and works as well, especially for those who may need less medication due to other health conditions.
This trial tests a new combination pill (xanomeline/trospium) for people who started treatment for schizophrenia in the last 5 years, to see if it helps better than their current medicine. You would stop your current antipsychotic and switch to this study drug under close doctor supervision.
This study tests whether a combination of a daily medication (olanzapine-samidorphan) and a structured exercise program can help people with schizophrenia, schizoaffective disorder, or bipolar disorder improve their health and well-being.
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This Phase 2 trial tests whether olanzapine can help people with advanced cancer who are losing weight and not eating enough. It looks for improvements in appetite and weight while you receive your first-line palliative cancer treatment.
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