Acetaminophen for preventing confusion after major surgery in older adults
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This trial tests whether giving acetaminophen (the pain reliever in Tylenol) through an IV can help prevent confusion or disorientation after major surgery in older adults. If you are 65 or older and scheduled for a major non-heart surgery lasting over 2 hours, this study may be for you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 65 years old or older.
- You will have a major surgery (not on the heart) under general anesthesia lasting more than 2 hours.
- You are in generally good health or have well-controlled medical conditions (ASA class I–III).
- You weigh over 110 pounds (50 kg).
- You do not have serious memory or thinking problems, a history of seizures or certain brain diseases, or severe heart issues.
- You do not have liver or kidney problems that prevent safe use of acetaminophen.
- You can communicate and do not have a history of alcohol or drug abuse in the past year.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether a low dose of the medicine esketamine can help prevent confusion after surgery in older adults at higher risk. You may qualify if you are 65 or older, planning a major non-cardiac surgery, and have certain health conditions like high blood pressure or diabetes.
This study tests whether a combination of sleep therapy, brain games, and light exercise before heart surgery can help prevent confusion or disorientation (delirium) after the operation. Participants will be asked to use a tablet and fitness tracker daily for about an hour before their surgery.
This trial tests if a combination of pain medicines (paracetamol and mannitol) given after surgery can reduce confusion or delirium in older patients in the ICU. It is for people aged 60 or older who have moderate to severe pain after a non-heart surgery.
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This trial tests giving either lidocaine or dexmedetomidine during abdominal surgery to see if it helps keep the brain healthy and lowers the chance of waking up confused or agitated. It is for older adults having planned abdominal surgery who are otherwise in fairly good health.
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