Pemigatinib for FGFR-altered advanced solid tumors
Treatments studied
Part of Cancer clinical trials.
This trial tests a targeted drug called pemigatinib for advanced solid tumors that have a specific change in the FGFR gene. The goal is to see if the drug can slow tumor growth for people who have few other treatment options.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a solid tumor (not blood cancer) that has spread or come back and cannot be surgically removed
- Your tumor must have a specific change (mutation or fusion) in the FGFR1, FGFR2, or FGFR3 gene
- You should be 18 or older and have a performance status that allows you to be up and about (ECOG 0-2)
- You must have no other standard treatment options, and you must not have taken a similar targeted drug before (like pemigatinib)
- You need to have had two scans (CT or MRI) at least 4 weeks apart showing the tumor is growing slowly but measurably (at least 0.1 mm per day)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of two drugs: pemigatinib (targets FGFR gene changes) and an immunotherapy (checkpoint inhibitor) for people with advanced solid tumors that have FGFR mutations. It may be a good option if standard treatments have failed and you have already tried immunotherapy.
This trial tests two targeted drugs, pemigatinib and afatinib, together for people with advanced solid tumors that have a specific FGFR genetic change. It may be an option if standard treatments have stopped working or aren't available.
This Phase 2 trial tests pemigatinib, a targeted medicine, for advanced or metastatic gastrointestinal (GI) cancers that have specific FGFR1–3 gene changes. It’s for people whose cancer has grown despite prior standard treatment, and who may benefit if their tumor has the right genetic change.
This trial tests a targeted pill, pemigatinib, for people with advanced pancreatic cancer that has a specific FGFR gene change. The study is done entirely through telemedicine, so you can participate from home if eligible.
This study tests a combination of two drugs—pemigatinib (a targeted therapy) and a PD-1 inhibitor (an immunotherapy)—with or without chemotherapy, for people with advanced bile duct cancer that has an FGFR2 fusion or rearrangement. The goal is to see if this combination is more effective than standard treatment, and to find better ways to treat this type of cancer.
This trial tests a drug called pemigatinib for people with a specific type of GIST (SDH-deficient GIST) that has spread or cannot be removed with surgery. The goal is to see if the drug can help stop the cancer from growing.
Hear when a new Solid Tumor, Miscellaneous trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.