Pemigatinib and immunotherapy for advanced solid tumors with FGFR changes
Treatments studied
Part of Cancer, Digestive system, Lungs & breathing, Skin clinical trials.
This trial tests a combination of two drugs—pemigatinib, which targets tumors with certain FGFR gene changes, and an immunotherapy drug that helps the immune system fight cancer—for people with advanced solid tumors that have not responded to standard treatments. The goal is to see if this combination can shrink tumors or slow their growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have an advanced solid tumor that has not responded to or you cannot tolerate standard treatments.
- Your tumor has a specific change in the FGFR1, FGFR2, or FGFR3 gene (like a mutation or fusion).
- You have not taken drugs that specifically block the FGFR pathway before, but you have been treated with an immune checkpoint inhibitor (a type of immunotherapy).
- You are in good general health (able to carry out daily activities) and have adequate organ function (like blood counts, liver, and kidneys).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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