Comparing a new clot-busting drug for severe stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests a medication called tenecteplase, given before a procedure to remove a large blood clot in the brain. It may help people who have had a severe stroke within the last 4.5 hours.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You had a stroke with symptoms starting less than 4.5 hours ago
- Your stroke is caused by a large blood clot in a major brain artery, confirmed by a scan
- Before the stroke, you could do your daily activities without help
- You or your family can give permission to be in the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study compares two medications, tenecteplase and alteplase, to see which works better at dissolving blood clots in people having an ischemic stroke. You may join if you can get treatment within 4.5 hours of when your symptoms started.
This study compares two treatment approaches for a stroke caused by a blocked brain artery: doing a procedure to remove the clot alone versus giving an IV clot-busting medicine first (tenecteplase). It aims to see which approach works better and is safest for improving recovery.
This trial tests a clot-busting drug called tenecteplase for people having a disabling ischemic stroke (a clot blocking blood flow to the brain). It aims to see if the drug can help improve recovery when given within 4.5 hours of symptoms starting.
This trial tests a medicine called tenecteplase (a clot-buster) for people who have a moderate or severe stroke caused by a clot and can be treated 4.5 to 6 hours after symptoms start. It aims to see if this medicine can help improve recovery.
This trial compares two clot-dissolving medications (tenecteplase and reteplase) given before a procedure to remove a large clot from a brain artery. It aims to see which drug works better for people who have had an acute ischemic stroke and are eligible for both treatments.
This trial tests whether giving a clot-busting drug (tenecteplase) before transferring you to a hospital that can do a procedure to remove the clot improves outcomes for people who had a stroke up to 24 hours earlier. You may qualify if you have a blockage in a large artery in the front of your brain and can still get the procedure.
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