Clot-busting drug for disabling stroke within 4.5 hours
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a clot-busting drug called tenecteplase for people having a disabling ischemic stroke (a clot blocking blood flow to the brain). It aims to see if the drug can help improve recovery when given within 4.5 hours of symptoms starting.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had a disabling stroke (not just mild symptoms like a little numbness or blurry vision).
- You arrived at the hospital within 4.5 hours of when symptoms started or when you were last seen healthy.
- You do not have any active bleeding, recent brain surgery, head injury, or bleeding disorder that would make clot-busting drugs unsafe.
- You are able to give consent (or have a family member/guardian do so) for the trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a medication called tenecteplase, given before a procedure to remove a large blood clot in the brain. It may help people who have had a severe stroke within the last 4.5 hours.
This study compares two treatment approaches for a stroke caused by a blocked brain artery: doing a procedure to remove the clot alone versus giving an IV clot-busting medicine first (tenecteplase). It aims to see which approach works better and is safest for improving recovery.
This trial tests whether giving a clot-busting drug to people with mild stroke symptoms (but no limb weakness) can improve recovery. It aims to see if this treatment is safe and helpful for this specific group.
This trial tests whether a stronger clot-busting drug (tenecteplase) is safe and works for people who have had a stroke while taking a common blood thinner. If you qualify, you may get this treatment within a few hours of your stroke to help improve recovery.
This trial tests whether giving a clot-busting drug called tenecteplase directly into the blocked blood vessel in the brain can help people with a medium-sized vessel occlusion stroke. The drug may help restore blood flow and reduce disability, and it is given within 24 hours of symptom onset.
This trial tests if giving a second dose of a clot-busting drug (tenecteplase) helps people who had a stroke and didn't improve much after the first dose. You must receive the second dose within 4.5 hours of your stroke symptoms starting.
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