Stroke clot-busting drug before transfer for artery clearing
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether giving a clot-busting drug (tenecteplase) before transferring you to a hospital that can do a procedure to remove the clot improves outcomes for people who had a stroke up to 24 hours earlier. You may qualify if you have a blockage in a large artery in the front of your brain and can still get the procedure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- Your stroke symptoms started between 4.5 and 24 hours before treatment.
- You had a stroke caused by a blockage in a large artery in the front part of your brain.
- You were able to do daily activities without help before the stroke.
- A brain scan shows a certain pattern that indicates you might benefit from this treatment.
- You are planned to be transferred for a procedure to remove the clot.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial compares two clot-busting drugs (tenecteplase or reteplase) given through an IV before a procedure to mechanically remove the clot (thrombectomy) in people with acute ischemic stroke. It aims to see which drug works better to restore blood flow and improve recovery.
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This trial tests a new clot-busting medicine called tenecteplase, given directly into the blood vessel in the brain, to treat strokes caused by a blockage in a medium-sized artery. The goal is to see if it can help restore blood flow and reduce disability, especially for patients who can be treated within 24 hours of stroke onset.
This trial tests whether a clot-dissolving drug called tenecteplase can improve recovery for people who had a large-vessel ischemic stroke 4.5 to 24 hours earlier and can’t have a mechanical clot removal procedure in time. If you join, you’ll get either tenecteplase or standard medical care, and the study will track your recovery and safety.
This trial tests whether giving a clot-busting drug called tenecteplase directly into the blocked blood vessel in the brain can help people with a medium-sized vessel occlusion stroke. The drug may help restore blood flow and reduce disability, and it is given within 24 hours of symptom onset.
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