Liver enzyme function in people with cardiogenic shock on heart pumps
Part of Heart & circulation clinical trials.
This study tests whether your liver’s drug-processing enzymes (CYP) work normally during cardiogenic shock when you are on a heart pump like ECMO or Impella®. The goal is to help doctors choose the right medicines for you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cardiogenic shock (heart too weak to pump enough blood) with or without a temporary heart pump like ECMO or Impella®.
- You are 18 years or older.
- You understand French and can give consent (a family member or legal representative can provide consent if needed).
- You do NOT have severe lung failure requiring a special lung bypass (VV-ECMO).
- You do NOT have severe kidney disease (GFR under 30) or severe liver disease (Child-Pugh B or C).
- You are not allergic to any of the study drugs: caffeine, midazolam, omeprazole, losartan, or dextromethorphan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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