Clin2
NCT06690840Possibly a fitRecruiting

Atezolizumab plus chemo for advanced triple-negative breast cancer

Triple Negative Breast Cancer

Part of Cancer, Skin clinical trials.

This trial tests atezolizumab (an immunotherapy) plus chemotherapy to activate immune cells in people with triple-negative breast cancer that has spread or cannot be removed. It is for those who have had immunotherapy before during early treatment but not for advanced disease.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
45 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have triple-negative breast cancer that has spread or cannot be removed, and your tumor is PD-L1 positive (has a certain immune cell marker).
  • You have already received a treatment like atezolizumab or similar immunotherapy during early-stage treatment (before cancer spread).
  • You have not had any chemotherapy, targeted therapy, or immunotherapy for advanced or metastatic disease.
  • You are 18 or older and have a performance status of 0-1 (able to do most daily activities).
  • You have at least one tumor that can be biopsied, and you agree to have samples taken.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06229067Not yet recruiting· Phase 2
Immunotherapy plus oral chemotherapy for advanced triple-negative breast cancer

This trial tests a combination of an immunotherapy drug (PD-L1 antibody) along with a low-dose oral chemotherapy ('metronomic') called VEX for people with advanced triple-negative breast cancer. The goal is to see if this combination is safe and effective in controlling the cancer.

NCT06078384Recruiting· Phase 2
Pembrolizumab and chemo for early-stage triple-negative breast cancer

This trial studies whether adding pembrolizumab (an immunotherapy) to standard chemotherapy after surgery can improve outcomes for people with early-stage triple-negative breast cancer. The treatment you receive depends on the level of immune cells (TILs) found in your tumor.

Amiens
NCT04301739Not yet recruiting· Phase 3
Immunotherapy plus chemo for triple-negative breast cancer

This trial tests whether adding an immunotherapy drug (HLX10) to chemotherapy before surgery, and then continuing it after surgery, helps people with triple-negative breast cancer more than chemotherapy alone. It is a type of breast cancer that does not respond to hormone treatments or HER2-targeted treatments.

NCT06318897Recruiting· Phase 2
Immunotherapy with chemo for early triple-negative breast cancer

This trial tests a combination of an immunotherapy drug (pembrolizumab) plus two chemotherapy drugs (carboplatin and paclitaxel) given before surgery for people with early-stage, triple-negative breast cancer. The goal is to see if this treatment helps shrink or eliminate the tumor before it's removed.

Houston, Texas
NCT06371807Not yet recruiting· Phase 2
Chemotherapy plus pembrolizumab before surgery for high-risk triple-negative breast cancer

This trial tests two different sequences of chemotherapy combined with pembrolizumab (an immunotherapy drug) given before surgery for high-risk triple-negative breast cancer. The goal is to see which sequence works better at shrinking or eliminating the tumor.

Lisbon
NCT06793553Recruiting· Phase 2
Induction chemo then immunotherapy for PD-L1 positive triple negative breast cancer

This trial tests a two-step approach: first a short course of chemotherapy (paclitaxel and bevacizumab), followed by a combination of immunotherapy (atezolizumab) and a different chemotherapy (nab-paclitaxel). It's for people with advanced triple-negative breast cancer that has spread or cannot be removed, and whose tumors have a specific marker called PD-L1. The goal is to see if this sequence works better than standard treatments.

Koto-ku, 3-8-31, Tokyo

Hear when a new Triple Negative Breast Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.