Induction chemo then immunotherapy for PD-L1 positive triple negative breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests a two-step approach: first a short course of chemotherapy (paclitaxel and bevacizumab), followed by a combination of immunotherapy (atezolizumab) and a different chemotherapy (nab-paclitaxel). It's for people with advanced triple-negative breast cancer that has spread or cannot be removed, and whose tumors have a specific marker called PD-L1. The goal is to see if this sequence works better than standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older, female or male.
- Your breast cancer is triple-negative (ER-negative, HER2-negative) and has a protein called PD-L1.
- Your cancer has come back or spread, but you have not yet had chemotherapy for this advanced stage.
- You are in good physical condition (ECOG 0-1).
- You have no active brain metastases.
- You have not had cancer treatment within the last 2 weeks, and your lab results are within safe ranges.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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