Plasma exchange daily vs every other day for Wilson disease liver failure in children
Treatments studied
Part of Brain & nervous system, Digestive system, Genetic & congenital, Hormones & metabolism clinical trials.
This study tests whether doing plasma exchange (a treatment that cleans the blood) every day works better than every other day for children with Wilson disease and acute liver failure. It may help your child's liver recover by removing harmful copper and waste products from the blood.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child has Wilson disease, a condition that makes the body hold onto copper.
- Your child is between 3 and 18 years old.
- The liver failure is serious enough to meet the study's score (New Wilson Index of 11 or higher).
- Your child's blood clotting test (INR) is 2.5 or higher, meaning the liver is not making enough clotting proteins.
- Your child is not in a coma or severely confused, does not have septic shock, and does not have severe heart or lung disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a higher volume of plasma exchange (cleaning the blood to remove toxins) works better than the standard amount for children with acute liver failure who are not improving with usual care.
This study compares giving a higher versus a standard amount of plasma exchange, a treatment that cleans your blood, to see if it helps people with sudden liver failure and brain swelling. It aims to find out if a higher dose can better reduce brain pressure and improve outcomes.
This study looks at how copper levels in urine change throughout the day and night in people with Wilson disease. If you take part, you will collect all your urine for 24 hours so researchers can measure copper at different times.
This study is looking at what happens to copper levels in the urine when people with Wilson disease briefly stop their medicine. It may help doctors understand how well your body controls copper without treatment.
This trial tests a new gene therapy called GC310 that may help treat Wilson disease, a genetic condition that causes copper to build up in the body. The therapy aims to fix the underlying cause, which could improve symptoms and quality of life.
This study looks at how Wilson's disease affects the kidneys. It aims to describe kidney problems in people with Wilson's disease, which may help doctors better monitor and treat this condition.
Hear when a new Acute Liver Failure trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.