Clin2
NCT06704594Possibly a fitRecruiting

Study of allopregnanolone for PMDD in women on SSRIs

Premenstrual Dysphoric Disorder (PMDD)

Treatments studied

Part of Mental health clinical trials.

This trial studies a natural brain chemical called allopregnanolone in women with premenstrual dysphoric disorder (PMDD) that responds to SSRI antidepressants. It aims to understand how the brain adapts and whether this treatment could help.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
288 people
Ages
18 years to 50 years
Study type
Interventional

Who can take part

  • You are female
  • You are between 18 and 50 years old
  • You have regular menstrual cycles (24 to 35 days)
  • You speak and understand English fluently
  • You have PMDD that improves with SSRI medication

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06771583Recruiting
Finding biomarkers for PMDD in blood samples

This study looks for chemical markers in the blood that might help diagnose PMDD. It involves blood draws and questionnaires over one or two menstrual cycles to see how your body responds to natural hormone changes.

Baltimore, Maryland
NCT07818720Not yet recruiting· Phase 1
Study of an experimental drug for severe PMS (PMDD)

This study tests an experimental medicine for premenstrual dysphoric disorder (PMDD), a severe form of PMS. It is a phase 1 trial, so the main goal is to check the drug's safety and how your body handles it, but it may also help assess its effectiveness.

NCT06238700Recruiting
Studying allopregnanolone for depression in midlife women

This trial tests whether allopregnanolone, a natural brain chemical, can help depression in women going through menopause. It compares the effects against a placebo to see if it improves mood symptoms.

Boston, Massachusetts
NCT06827431Not yet recruiting· Phase 3
Study of ammoxetine for depression

This study tests a new medicine called ammoxetine for people with major depression. It aims to see if it can help reduce depressive symptoms.

NCT07079761Recruiting· Phase 2
PTSD treatment study with a hormone-like drug

This trial tests if a single infusion of allopregnanolone (a natural brain chemical) can help people with PTSD reduce fear responses and improve memory processing. It may offer a new way to treat PTSD by targeting how the brain stores traumatic memories.

Boston, Massachusetts
NCT06610305Recruiting· Phase 4
Hormones, mood, and reward in women with PMS-related depression

This study looks at how changes in hormone levels during the menstrual cycle affect mood and the brain's reward system in women with depression that gets worse before their period. The goal is to understand why this happens so better treatments can be developed.

Chapel Hill, North Carolina

Hear when a new Premenstrual Dysphoric Disorder (PMDD) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.