Pregnenolone for alcohol use disorder and depression
Treatments studied
Part of Mental health clinical trials.
This study tests a natural hormone called pregnenolone to see if it helps people who have both alcohol use disorder and depression. Participants will take the study drug or a placebo and undergo brain scans to see if it changes brain activity related to these conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 21 and 55 years old.
- You must have a diagnosis of alcohol use disorder (problem drinking).
- You must also have a diagnosis of major depressive disorder (clinical depression).
- You cannot have bipolar disorder, schizophrenia, or another psychotic disorder.
- You must be able to have an MRI scan (no metal in your body, no pacemaker, etc.).
- You must not be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a natural supplement called pregnenolone to see if it helps reduce cannabis use and improve depression. Participants receive the study drug or a placebo and are monitored over time.
This study tests an investigational drug (pregnenolone) to see if it can help veterans who have both PTSD and alcohol use disorder. The goal is to find the right dose that might reduce stress-related drinking.
This study tests whether psilocybin (a psychedelic compound) combined with talk therapy can help people who have both major depression and alcohol use disorder. The goal is to see if it can improve mood and reduce drinking.
This study is testing whether ketamine, given alongside therapy, can help people who have both alcohol use disorder and depression. The goal is to see if this combination reduces drinking and improves mood.
This Phase 2 study tests pregnenolone to help reduce or improve alcohol use disorder symptoms. It looks for adults who drink regularly and meet diagnostic criteria for moderate to severe alcohol use disorder, while excluding people with certain other substance use, medicines, or serious mental/medical conditions.
This study tests whether a dietary supplement called pregnenolone can improve day-to-day function in veterans struggling with anxiety and depression. It is a 12-week program that combines the supplement with your usual care, and the goal is to help you feel better and do more of what matters to you.
Hear when a new Alcohol Use Disorder (AUD) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.