Sirolimus for treating vertebrobasilar dolichoectasia
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether sirolimus, a medication that may slow blood vessel changes, can help people with a condition called vertebrobasilar dolichoectasia (VBD), where a major artery in the brain becomes enlarged and twisted. If you have had symptoms or a stroke related to VBD, this study might offer a new treatment option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with vertebrobasilar dolichoectasia (VBD) using imaging tests like DSA, CTA, or MRA.
- You have not had a rupture of VBD or surgery for it.
- You are able to care for yourself (score less than 4 on the modified Rankin Scale).
- You have a positive blood test for something called plasma SGK1.
- You have had a stroke in the back of the brain or have symptoms related to VBD.
- You are either taking both an antiplatelet drug and a statin, or you are not taking either of them.
- You can understand and sign the consent form, with a guardian if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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