Clin2
NCT06749691Possibly a fitRecruiting

Liposomal irinotecan and apatinib for extensive-stage small cell lung cancer

Small Cell Lung Cancer Extensive Stage

Part of Cancer, Lungs & breathing clinical trials.

This trial tests a combination of two drugs, liposomal irinotecan and apatinib, for people with extensive-stage small cell lung cancer (ES-SCLC) that has progressed after first or second line treatment. The goal is to see if this new combination can help shrink tumors or slow the cancer's growth.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
30 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are between 18 and 75 years old.
  • Your doctor expects you to live at least 12 more weeks.
  • You have at least one tumor that can be measured on a scan.
  • Your cancer has gotten worse after one or two prior treatments for ES-SCLC.
  • You have not taken any drug that blocks the VEGF or VEGFR pathway (like avastin, apatinib, or other similar medicines) before.
  • You do not have an active infection or need antibiotics within the last 2 weeks, and you can swallow pills without trouble.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06786312Not yet recruiting· Phase 2
Apatinib plus adebrelimab and chemo for extensive small cell lung cancer

This trial tests a new combination of two targeted/immune drugs with standard chemotherapy as a first treatment for extensive small cell lung cancer. It aims to see if this approach is safe and effective for people who have not had prior treatment for this cancer.

Fuzhou, Fujian
NCT06429696Recruiting· Phase 2
Maintenance therapy for extensive stage small cell lung cancer

This study tests if a combination of an immunotherapy drug (PD-L1 inhibitor) and a targeted therapy pill (apatinib) can help keep extensive stage small cell lung cancer from growing after initial treatment. It is for people whose cancer was controlled with first-line chemo-immunotherapy.

Guangzhou, Guangdong
NCT06739928Recruiting· Phase 2
Irinotecan liposome with immunotherapy for extensive-stage small cell lung cancer

This trial tests a combination of irinotecan liposome (a chemotherapy) or etoposide with adebrelimab (an immunotherapy) and carboplatin for people with extensive-stage small cell lung cancer who haven't had prior treatment. It aims to see if these combinations are safe and effective.

Guangzhou, Guangzhou
NCT06982287Not yet recruiting
Maintenance therapy with anlotinib and immunotherapy for extensive-stage small cell lung cancer

This trial is testing whether a maintenance therapy using anlotinib (a drug that blocks blood vessel growth) combined with immunotherapy can help keep extensive-stage small cell lung cancer from progressing after initial chemoimmunotherapy. It aims to see if this reduces the chance of the cancer coming back and improves survival.

NCT06332950Not yet recruiting· Phase 1/Phase 2
Combination treatment for small cell lung cancer after immunotherapy

This trial tests a combination of two drugs, adebrelimab and irinotecan liposome, with or without a third drug called famitinib, for people with extensive-stage small cell lung cancer that has progressed after initial treatment with immunotherapy. The goal is to see if this combination can help control the cancer.

Shanghai
NCT06258642Recruiting
Irinotecan liposome plus anlotinib for SCLC after first chemo

This trial tests a combination of two drugs—irinotecan liposome (a chemotherapy) and anlotinib (a targeted therapy)—as a second treatment for small cell lung cancer that returned quickly after initial chemo. The goal is to see if this combo can work better than standard options.

Shanghai, Shanghai Municipality

Hear when a new Small Cell Lung Cancer Extensive Stage trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.