Lower-dose radiation before stem cell transplant for older adults with aplastic anemia
Part of Blood & lymphatic clinical trials.
This trial tests a gentler conditioning regimen (using lower-dose radiation) before a stem cell transplant for people aged 50 and older with aplastic anemia. The goal is to make the transplant safer and more tolerable for older patients.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 50 years old or older.
- You have been diagnosed with aplastic anemia (including severe, very severe, chronic, or hepatitis-related).
- You have not had more than one previous stem cell transplant.
- You do not have an active infection, severe liver or kidney problems, or active cancer (other than certain skin cancers).
- You are able to sign the consent form yourself or have a legal guardian or family member do it for you.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new combination of drugs to prepare older patients (40–60 years old) with severe aplastic anemia for a stem cell transplant from a half-matched donor. The goal is to make the transplant safer and more effective for this age group.
This trial compares two standard treatments for severe aplastic anemia (a condition where the bone marrow stops making enough blood cells). One treatment is a stem cell transplant from a donor, and the other is a drug therapy that suppresses the immune system. The goal is to see which works better as a first treatment.
This trial tests a new way of using a mix of donor stem cells (from a half-matched family member and a cord blood unit) to treat aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal is to see if this transplant approach is safe and helps rebuild healthy blood cells.
This trial tests a special combination of chemotherapy drugs (called a conditioning regimen) given before a half-matched stem cell transplant for older adults with acute myeloid leukemia (AML) in their first remission. The goal is to make the transplant safer and more effective for people aged 55 to 75.
This study is testing whether a stem cell transplant (from a matched relative, unrelated donor, or half-matched donor) can help adults aged 40–60 with severe aplastic anemia that didn't get better or came back after standard treatments.
This Phase 1 trial tests a “lower-intensity” chemotherapy plan followed by a stem cell transplant from a related half-match donor for severe aplastic anemia that has returned or did not respond to prior medicines. It aims to see if this approach is safe and works well enough to help your blood counts recover.
Hear when a new HSCT trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.