Tenecteplase after clot removal for severe stroke
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests if giving a clot-busting drug (tenecteplase) directly into the brain artery after a successful clot-removal procedure can improve outcomes for people with a major stroke. It is for patients who had a large vessel blockage and received endovascular thrombectomy within 24 hours of symptoms starting.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You or your legal representative must sign a consent form
- Before your stroke, you could live independently (able to do daily tasks alone)
- Your stroke must be from a blockage in one of the large arteries in your brain (internal carotid or middle cerebral)
- You had a clot-removal procedure (thrombectomy) that reopened the artery, and a brain scan shows a large zone of at-risk tissue
- You must meet specific brain scan criteria showing a mismatch between damaged and salvageable brain tissue
- You cannot have active bleeding, low platelets, uncontrolled high blood pressure, or other serious medical conditions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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