Clot-busting drug vs standard care for late large-vessel stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether a clot-dissolving drug called tenecteplase can improve recovery for people who had a large-vessel ischemic stroke 4.5 to 24 hours earlier and can’t have a mechanical clot removal procedure in time. If you join, you’ll get either tenecteplase or standard medical care, and the study will track your recovery and safety.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You had an ischemic stroke (a clot blocking blood flow in the brain) and it’s been 4.5 to 24 hours since you were last known to be well.
- Before the stroke, you could live independently (score 0-2 on the modified Rankin Scale).
- Your stroke is moderately severe (NIHSS score between 6 and 25).
- Brain scans show a blockage in a large artery (like the middle cerebral artery) and you can’t get clot removal surgery within the standard time frame.
- You must not have recent major bleeding, a bleeding disorder, or be on blood thinners that increase bleeding risk.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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