Statin to prevent plaque buildup during melanoma immunotherapy
Treatments studied
Part of Cancer, Heart & circulation, Skin clinical trials.
This study tests whether the statin drug atorvastatin can prevent immunotherapy from worsening artery plaque in people with melanoma. It aims to lower the risk of heart problems caused by treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have melanoma and are planning to start immunotherapy (like nivolumab, pembrolizumab, or ipilimumab).
- You have plaque buildup (atherosclerosis) in the main artery in your chest (the aorta).
- You are not currently using a statin and haven’t had a bad reaction to statins before.
- You do not have advanced liver or kidney disease, a muscle disorder, or certain medication conflicts (like some antibiotics, antifungals, or fibrates).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies whether taking a cholesterol medicine called a statin can slow the buildup or worsening of coronary artery plaque in people with melanoma who are receiving checkpoint inhibitor (immunotherapy) treatment. It mainly looks at heart scans over time to see if statins change the progression of coronary atherosclerosis.
This study tests whether giving aggressive cholesterol-lowering medication to people starting immunotherapy for melanoma can improve heart health. It may help reduce the risk of heart problems during cancer treatment.
This trial studies whether a combination of atorvastatin and omega-3 can reduce signs of artery plaque in people with type 2 diabetes and “mixed” cholesterol problems. It’s focused on people who don’t have symptoms from plaque yet.
This study looks at how certain cancer drugs (called immune checkpoint inhibitors) interact with other medicines in the body. It aims to help doctors understand how to safely combine these treatments.
This study tests whether taking mesalamine can prevent colitis (bowel inflammation) in people with advanced melanoma who are treated with ipilimumab plus nivolumab. It may help reduce dangerous stomach or bowel side effects from this cancer treatment.
This Phase 3 study tests whether taking atorvastatin (a cholesterol-lowering medicine) can improve outcomes for women with estrogen-receptor–positive breast cancer. It may help by affecting cancer-related pathways and reducing risk of recurrence or progression.
Hear when a new Atherosclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.