Short radiation and chemo with or without immunotherapy for rectal cancer
Part of Cancer clinical trials.
This trial tests if adding an immunotherapy drug (PD-1 inhibitor) and a targeted therapy (bevacizumab) to short-course radiation followed by chemo can improve outcomes for patients with locally advanced rectal cancer that is pMMR/MSS. The goal is to shrink the tumor before surgery and possibly avoid the need for more extensive treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stage II or III rectal cancer (tumor is within 12 cm of the anal opening).
- You have not had any prior treatment for rectal cancer (like radiation, chemo, or immunotherapy).
- Your tumor is MSS or pMMR (a specific genetic type).
- You are between 18 and 75 years old, in generally good health, and able to undergo surgery with curative intent.
- You have adequate organ function and are willing to provide blood and tumor samples for research.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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