Shorter radiation with immunotherapy for rectal cancer
Part of Cancer clinical trials.
This trial tests a shorter course of radiation followed by a combination of chemotherapy, immunotherapy, and a targeted drug (bevacizumab) for locally advanced rectal cancer that is mismatch repair proficient (pMMR) or microsatellite stable (MSS). The goal is to see if this approach can shrink the tumor enough for surgery while avoiding more extensive radiation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with rectal adenocarcinoma (a type of cancer) that has not spread to other organs.
- Your tumor is located within 10 cm of the anal opening and is stage II or III (locally advanced).
- Your tumor shows normal levels of certain repair proteins (called pMMR) or is microsatellite stable (MSS).
- You have not had any prior treatment for this cancer, such as radiation, chemotherapy, or immunotherapy.
- You are between 18 and 75 years old and have a good daily activity level (ECOG 0 or 1).
- You are willing to provide tumor tissue and blood samples for testing.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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