Inhaled colistin to prevent pneumonia in ventilated patients
Treatments studied
Part of Infections, Lungs & breathing clinical trials.
This trial tests if inhaling a medication called colistin can prevent ventilator-associated pneumonia (a lung infection) in patients who are on a breathing machine. It aims to reduce the risk for those at high risk of getting an infection from drug-resistant bacteria.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have been on a breathing machine (ventilator) for at least 2 days.
- You have at least one risk factor for a hard-to-treat bacterial infection, such as recent antibiotics, long hospital stay, septic shock, ARDS, kidney dialysis, or previous infection with resistant bacteria.
- You do not already have a lung infection from the ventilator and are not expected to have the breathing tube removed in the next 24 hours.
- You are not allergic to colistin, have not used it recently, and do not have severe kidney problems (unless on dialysis).
- You are not pregnant, breastfeeding, or expected to live less than 48 hours.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving an inhaled antibiotic called colistin can prevent pneumonia in patients with brain injuries who are on ventilators. If effective, it could reduce lung infections and improve recovery.
This study tests whether adding an inhaled antibiotic (polymyxin) to standard IV antibiotics helps treat a severe lung infection that is resistant to many drugs. It is for people who had a stroke and developed this infection while on a breathing machine. The inhaled drug is delivered directly to the lungs, which might improve treatment and reduce side effects.
This trial tests whether inhaling an antibiotic called amikacin can prevent ventilator-associated pneumonia in patients with severe liver disease (cirrhosis) who are on a breathing machine. If you or your loved one is in the ICU with liver issues and needs a ventilator, this study may help reduce the risk of a serious lung infection.
This trial tests whether giving preventive antibiotics to adults on breathing machines lowers the risk of developing pneumonia during ventilation. It is a double-blind study, meaning neither you nor your doctor will know if you receive the antibiotic or a placebo.
This trial tests whether using a rapid test to find the exact bacteria causing your pneumonia can help doctors choose the right antibiotics faster, which might improve your recovery. The study compares this approach to usual care in patients on ventilators.
This trial tests whether giving a nebulized (inhaled) antibiotic called colistimethate sodium can prevent ventilator-associated pneumonia (a lung infection) in children who are on a breathing machine. If it works, this could reduce the risk of serious lung infections in hospitalized children.
Hear when a new Ventilator-Associated Pneumonia (VAP) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.