Clin2
NCT06835140Possibly a fitRecruiting

NK cell immunotherapy for AML that has stopped responding to treatment

AML (Acute Myelogenous Leukemia)NK CellCD123+ Acute Myeloid Leukemia

Part of Blood & lymphatic, Cancer clinical trials.

This trial tests a new type of immunotherapy using special immune cells (NK cells) that target the CD123 marker found on AML cells. It may help people whose AML has not responded to standard treatments and who have a healthy donor available.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
9 people
Ages
18 years to 70 years
Study type
Interventional

Who can take part

  • You are between 18 and 70 years old.
  • You have AML that has stopped responding to at least one round of standard treatments.
  • Your AML cells have a specific marker called CD123 at a level of 20% or more.
  • You have a healthy donor willing to donate blood cells for this therapy.
  • You are not pregnant, breastfeeding, or have certain uncontrolled infections or heart conditions.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06641648Recruiting· Phase 1
Donor NK cells with low-dose IL-2 for AML relapse after stem cell transplant

This trial tests a new treatment for patients whose acute myeloid leukemia (AML) has come back after a stem cell transplant. It uses immune cells from the original donor, combined with a low dose of a protein called IL-2, to try to fight the leukemia without causing severe side effects.

Beijing, Beijing Municipality
NCT06201247Recruiting· Early Phase 1
CD123-targeted immune cell therapy for relapsed/refractory AML

This early-phase trial tests an 'off-the-shelf' immune cell treatment (CAR-NK cells) that targets a protein called CD123 on leukemia cells. It's for people with AML that has returned or hasn't responded to standard treatments.

Beijing, Beijing Municipality
NCT04662788Not yet recruiting· Early Phase 1
NK cells with antibodies for blood cancer

This trial tests a treatment using natural killer (NK) cells combined with antibodies to fight a type of blood cancer called acute myeloid leukemia (AML). It is for people whose AML has come back or not improved with standard treatments.

Hangzhou, Zhejiang
NCT06885476Recruiting
NK cell infusion for AML patients with minimal cancer left

This trial tests if giving special immune cells from a donor can clear leftover leukemia cells in patients who are in remission but still have traces of cancer after chemotherapy.

Bologna, BO
NCT05503134Recruiting· Phase 1/Phase 2
Donor immune cell treatment for relapsed or stubborn AML

This trial tests donated “natural killer (NK) cells,” a type of immune cell, in children and young adults with AML that has come back or did not respond to treatment. It mainly looks at safety and also studies whether the treatment can help control the leukemia.

Columbus, Ohio
NCT06138587Recruiting· Phase 1
NK cell therapy after stem cell transplant for high-risk blood cancers

This trial tests whether giving specially trained natural killer (NK) cells after a stem cell transplant can help prevent relapse in people with high-risk blood cancers like AML, MDS, or MDS/MPN. You receive one infusion of these cells about a week after your transplant.

Boston, Massachusetts

Hear when a new AML (Acute Myelogenous Leukemia) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.