Pill alone vs. pill plus banding to prevent variceal bleeding in liver cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial compares two approaches to prevent first-time bleeding from enlarged veins in the food pipe (varices) in people with liver cancer and cirrhosis. One group receives a daily pill (carvedilol), and the other receives the pill plus a procedure (endoscopic banding) to tie off the veins.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have cirrhosis (liver scarring) and liver cancer (HCC).
- You have large or high-risk esophageal varices (enlarged veins in the food pipe that could bleed).
- You can safely take a beta-blocker medication (like carvedilol).
- You have not had a previous variceal bleed, and you are not scheduled for a liver transplant in the next 2 weeks.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether tying off high-risk veins in the esophagus before starting a common liver cancer treatment can prevent bleeding. It is for people with liver cancer that has spread but who have never had cancer treatment before.
This study compares two ways to stop variceal bleeding (bleeding from swollen veins in the esophagus or stomach) from coming back in people with liver cancer. It tests whether an ultrasound-guided technique during endoscopy can reduce repeat bleeding compared with standard endoscopy methods.
This trial tests whether adding metformin to carvedilol (a standard drug) lowers liver pressure more than carvedilol alone in people with cirrhosis who have had variceal bleeding. The goal is to prevent future bleeding.
This trial tests whether carvedilol can prevent the first development of swollen veins (varices) in the esophagus in people with cirrhosis who do not have them yet. It may help lower the risk of future bleeding from those veins.
This trial tests if adding midodrine to carvedilol is better than carvedilol alone at preventing another bleed from varices in patients with cirrhosis who have had a high-risk variceal bleed.
This trial compares two treatments (banding or a medication called carvedilol) to prevent the first episode of bleeding from enlarged veins in the esophagus in people with liver cancer. The goal is to find which approach is safer and more effective.
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