Two drugs to prevent repeat variceal bleeding
Treatments studied
Part of Digestive system clinical trials.
This study tests whether adding a second drug (midodrine) to the standard drug (carvedilol) is better at preventing another bleeding episode from varices in people with cirrhosis. It aims to reduce the risk of early re-bleeding and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cirrhosis and have had a high-risk variceal bleed (bleeding from swollen veins in your food pipe or stomach).
- Your age is between 18 and 75.
- You are not currently on beta-blockers or midodrine (within the last 5 days).
- You have not had TIPS or a portosystemic shunt procedure.
- You do not have severe complications like kidney injury, heart problems, or certain cancers.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether adding metformin to carvedilol (a standard drug) lowers liver pressure more than carvedilol alone in people with cirrhosis who have had variceal bleeding. The goal is to prevent future bleeding.
This study compares two ways to prevent future bleeding from enlarged veins in the esophagus or stomach in people with liver cirrhosis. One method uses a small tube (called TIPS) to reduce pressure in the liver, and the other combines a banding procedure with medication. The goal is to see which approach works better.
This trial tests a slightly smaller TIPS stent (underdilated) against the standard size to see which is better at preventing another variceal bleed in people with cirrhosis and liver scarring. It aims to find the safest way to lower pressure in the veins while reducing side effects.
This study compares two ways to prevent bleeding from enlarged veins in the esophagus (varices) in people with liver cancer and cirrhosis. One method uses a medication called carvedilol alone, while the other combines carvedilol with a procedure called band ligation, which ties off the veins to prevent bleeding.
This trial tests whether carvedilol can prevent the first development of swollen veins (varices) in the esophagus in people with cirrhosis who do not have them yet. It may help lower the risk of future bleeding from those veins.
This trial tests whether carvedilol or propranolol works better to prevent another bleeding episode from enlarged veins in the stomach or esophagus (varices) after they have been treated with endoscopy. If you have cirrhosis and had a variceal bleed 6 to 30 days ago, this study may help find the most effective medicine for you.
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