Two ablation methods for persistent atrial fibrillation
Part of Heart & circulation clinical trials.
This study compares two extra ablation procedures done along with standard pulmonary vein isolation in people with persistent atrial fibrillation. Both aim to stop abnormal electrical signals that drive atrial fibrillation, and the study will see which approach is safer and more effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have persistent atrial fibrillation (a heart rhythm problem that lasts for more than a week) that causes symptoms like palpitations, shortness of breath, or fatigue.
- You are between 18 and 85 years old.
- If you've had a prior ablation, it was only for isolating the pulmonary veins (the vessels carrying blood from your lungs to your heart) — not for other parts of the left atrium.
- Your heart's pumping function is normal or only mildly reduced (left ventricular ejection fraction of 40% or higher).
- You do NOT have a blood clot in the left atrium, and you have not had a heart attack in the last 60 days or heart surgery in the last 6 months.
- Your kidneys are working well enough (no advanced kidney failure), and you are not pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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