Can a special diet or pills help liver health?
Part of Digestive system, Heart & circulation, Hormones & metabolism clinical trials.
This study compares two treatments for liver scarring in people with overweight or related health issues. One group follows a special diet with restricted eating times, while the other takes a combination of two medications (naltrexone and bupropion). It aims to see which approach better improves liver fibrosis.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 75 years old.
- Your body mass index (BMI) is over 30, or over 27 with at least one condition like type 2 diabetes, high blood pressure, or abnormal cholesterol.
- You have moderate to severe liver scarring (fibrosis), confirmed by a special ultrasound scan.
- You can understand and communicate in Dutch (spoken and written).
- You are not pregnant, breastfeeding, or planning to become pregnant.
- You have no other serious liver diseases (like hepatitis B or C, autoimmune hepatitis, or alcoholic liver disease).
- You have not had a liver transplant or been placed on a transplant list.
- You do not have cirrhosis or related complications like fluid in the belly or bleeding in the throat.
- You do not have an active HIV infection or cancer.
- Your kidney function is not severely reduced (eGFR is 30 or higher).
- You have not had weight loss surgery that still affects your weight.
- You do not use certain medications like MAO inhibitors, opioids, or methadone.
- You do not drink more than 2-3 alcoholic drinks per day.
- If you use GLP-1 agonist medications (like Ozempic), you have been on a steady dose for at least 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a new drug called AZD2389 is safe and well-tolerated in adults with steatotic liver disease (fatty liver) that has progressed to advanced scarring. The trial aims to see if this drug might help slow or improve liver damage in people with this condition.
This trial tests whether a very low calorie ketogenic diet (a strict low-carb, high-fat diet) can help people with non-alcoholic steatohepatitis (NASH) who have liver scarring. Participants will follow this diet for a year and have two liver biopsies to see if their liver health improves.
This study uses routine blood tests to find people with advanced liver scarring caused by a condition called MASLD. If you are between 50 and 75, have certain metabolic risks, and get blood work from your primary care doctor at select centers, you may be eligible.
This study tests if weight loss surgery can improve liver fibrosis (scarring) in people with obesity and advanced liver disease. It may help those considering surgery to know if their liver health can get better.
This study tests whether adding a liver stiffness measurement to a lifestyle program helps people with MASLD (a type of fatty liver disease) improve their liver health. It is designed for people who have fatty liver and at least one sign of metabolic syndrome, like high blood pressure or diabetes.
This study is testing whether advanced imaging and other non-invasive methods can properly identify people with significant liver scarring due to metabolic liver disease or alcohol-related liver disease. It may help find better ways to track liver health without repeated needle biopsies.
Hear when a new Liver Fibrosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.