Comparing heart valves for small aortic openings
Part of Heart & circulation clinical trials.
This trial compares different types of heart valves (surgical and less-invasive) used in people with a small heart valve opening. It aims to see which valves work best, and will follow up with patients who already had the procedure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had severe narrowing of your aortic valve (aortic stenosis) and got a new valve, either through open-heart surgery (SAVR) or a less invasive procedure (TAVI).
- The valve you received is one of the specific models and sizes that are being tested in this study.
- You do not have an untreated bulge in the main artery from your heart (aortic root or ascending aorta aneurysm).
- You did not have a heart attack or a blocked-artery procedure in the last 12 weeks.
- You do not have a permanent pacemaker and your heart rhythm is not from a pacemaker (it should be in normal sinus rhythm).
- You do not have a moderate or severe leak around the valve (paravalvular leak).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares two newer types of replacement heart valves (SAPIEN 3 Ultra Resilia and Evolut FX) to see which one works better for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. If you join, you'll be randomly assigned to receive one of the two valves during your TAVI procedure.
This trial tests two types of replacement heart valves (self-expanding and balloon-expanding) in people who have severe aortic stenosis (tight heart valve) and an enlarged aorta (the main blood vessel from the heart). The goal is to see which valve type works better for these patients.
This study compares two types of replacement heart valves used in a procedure to treat aortic stenosis (a narrowed heart valve). It aims to see which valve is safer by measuring tiny particles that may travel to the brain during the procedure.
This trial studies whether a new through-the-blood-vessel heart valve (TAVR) is safe and works well for people with severe aortic stenosis who are too risky for traditional surgery. If you qualify, you would be closely followed to check your symptoms and valve function over time.
This study checks if measurements taken from a CT scan before surgery match the actual size of the valve measured during surgery. It may help doctors choose the best valve size for people with severe aortic stenosis who need valve replacement.
This study checks whether an “investigational” transcatheter aortic valve is safe and works well for people with severe, calcified aortic stenosis (a stiff, narrowed heart valve). It may help improve valve function and symptoms, but you must meet specific heart, scan, and health-status requirements.
Hear when a new Severe Aortic Valve Stenosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.