MRI test to measure brain vessel health in CADASIL
Part of Brain & nervous system, Genetic & congenital, Heart & circulation clinical trials.
This study uses MRI scans to look at how well the small blood vessels in the brain work in people with CADASIL, a genetic condition that can cause strokes and cognitive problems. The goal is to develop a new test to better understand and monitor the disease. Participants will have an MRI and may also do simple tasks during the scan.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 80 years old.
- For patients: A genetic test shows a NOTCH3 gene change typical of CADASIL.
- You must be covered by health insurance (in France).
- You must be able to have an MRI (no metal implants, pacemaker, etc.).
- If you have CADASIL, you must not have severe disability (Rankin score less than 4) or severe dementia (MMSE above 19).
- If you are a healthy control, you must be free of any major medical conditions such as high blood pressure, diabetes, or smoking.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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