CADASIL Study: Genes, Brain Scans and Symptoms
Part of Brain & nervous system, Genetic & congenital, Heart & circulation clinical trials.
This study looks at how genetic and brain imaging changes relate to symptoms in people with CADASIL, a genetic condition that affects small blood vessels in the brain and can cause strokes. It aims to better understand the disease to improve future care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years old or older.
- You need to have a confirmed CADASIL diagnosis — either through a genetic test showing a NOTCH3 mutation, or through a skin biopsy that found specific deposits in your small blood vessels.
- You must be able to understand the study and give your consent to participate. If you cannot, a family member can give permission for you.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is building a group of Australians with CADASIL (a genetic condition that affects blood vessels in the brain) to learn more about the disease. As a participant, you will have a medical exam, a blood test, and a short memory test.
This trial studies CADASIL (a genetic blood-vessel condition in the brain) by following people over time with MRI scans, blood draws, and questionnaires. It may help researchers better understand how the condition changes and how factors like medications affect outcomes.
This study builds a group “registry” of people affected by CADASIL (a genetic brain blood-vessel condition) and people who carry the NOTCH3 mutation, even if they have no symptoms. It helps researchers learn more about the condition over time and compare experiences between patients, carriers, and healthy relatives or controls.
This study follows people with CADASIL over time to learn more about the condition. It may help researchers understand how CADASIL progresses and improve care for patients.
This study uses MRI scans to look at how well the small blood vessels in the brain work in people with CADASIL, a genetic condition that can cause strokes and cognitive problems. The goal is to develop a new test to better understand and monitor the disease. Participants will have an MRI and may also do simple tasks during the scan.
This trial looks at people who may have “small vessel” problems in the brain, which can cause stroke, memory trouble, walking changes, movement symptoms, or headaches. It may help researchers better understand the genetic and non-genetic causes, which could improve future diagnosis and treatment.
Hear when a new CADASIL trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.