Study for CADASIL using MRI, blood tests, and follow-up visits
Part of Brain & nervous system, Genetic & congenital, Heart & circulation, Mental health clinical trials.
This trial studies CADASIL (a genetic blood-vessel condition in the brain) by following people over time with MRI scans, blood draws, and questionnaires. It may help researchers better understand how the condition changes and how factors like medications affect outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 18 or older
- Have confirmed CADASIL through NOTCH3 genetic testing or a skin biopsy, or be willing to get NOTCH3 genetic testing before enrolling
- Be willing to come for in-person visits at the start, 18 months, and 36 months, plus remote check-ins as needed
- Be able to get an MRI scan and provide a blood sample at each in-person visit
- Bring a study companion—someone who knows you well and can answer questions
- Have limited disability—score less than 4 on the Modified Rankin Scale (a disability rating)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is building a group of Australians with CADASIL (a genetic condition that affects blood vessels in the brain) to learn more about the disease. As a participant, you will have a medical exam, a blood test, and a short memory test.
This study looks at how genetic and brain imaging changes relate to symptoms in people with CADASIL, a genetic condition that affects small blood vessels in the brain and can cause strokes. It aims to better understand the disease to improve future care.
This study is testing a new brain scan tool to understand small blood vessel problems in people with CADASIL. If you have CADASIL, you'll have an MRI to help develop a way to spot these changes earlier.
This study builds a group “registry” of people affected by CADASIL (a genetic brain blood-vessel condition) and people who carry the NOTCH3 mutation, even if they have no symptoms. It helps researchers learn more about the condition over time and compare experiences between patients, carriers, and healthy relatives or controls.
This study follows people with CADASIL over time to learn more about the condition. It may help researchers understand how CADASIL progresses and improve care for patients.
This study collects blood samples and medical information from people with rare inherited blood vessel diseases of the brain, and from healthy volunteers. Researchers use this information to understand these diseases better and develop future treatments.
Hear when a new CADASIL trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.