Study for CADASIL using MRI, blood tests, and follow-up visits
Part of Brain & nervous system, Genetic & congenital, Heart & circulation, Mental health clinical trials.
This trial studies CADASIL (a genetic blood-vessel condition in the brain) by following people over time with MRI scans, blood draws, and questionnaires. It may help researchers better understand how the condition changes and how factors like medications affect outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 18 or older
- Have confirmed CADASIL through NOTCH3 genetic testing or a skin biopsy, or be willing to get NOTCH3 genetic testing before enrolling
- Be willing to come for in-person visits at the start, 18 months, and 36 months, plus remote check-ins as needed
- Be able to get an MRI scan and provide a blood sample at each in-person visit
- Bring a study companion—someone who knows you well and can answer questions
- Have limited disability—score less than 4 on the Modified Rankin Scale (a disability rating)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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