PCSK9 Inhibitors for High-Risk Coronary Plaques on CT
Part of Heart & circulation clinical trials.
This study tests whether adding a PCSK9 inhibitor (a newer cholesterol-lowering shot) to standard treatment can reduce heart risks in people who have certain high-risk plaque features seen on a CT scan of their heart arteries.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a CT scan of your heart arteries that shows a blockage of 50% or more (or a lot of plaque) with at least 2 high-risk features (such as soft plaque, outward bulging, a ring-like sign, or tiny calcium spots).
- The blocked area is in the main part of one of the three main heart arteries.
- You do NOT have a recent heart attack or unstable angina.
- You do NOT have severe heart failure or a very weak heart pump.
- You are not pregnant or breastfeeding, and you are not allergic to statins or PCSK9 inhibitors.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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