Combination painkiller vs celecoxib for osteoarthritis flare-ups
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with osteoarthritis in your knee or hip.
- Your pain is moderate to severe (4 or higher on a 0–10 pain scale) and the flare-up has lasted no more than 3 weeks.
- You are not allergic to NSAIDs (like ibuprofen) or acetaminophen (Tylenol).
- You have not taken other NSAIDs or COX-2 inhibitors in the last 72 hours (except low-dose aspirin for heart protection).
- You have not had any opioid painkillers in the last 5 days.
- If you are able to have children, you agree to use effective birth control during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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