Clin2
NCT06890585Possibly a fitNot yet recruiting

New drug combination for double-expressor lymphoma

BTK InhibitorsHistone Deacetylase InhibitorDouble Express Diffuse Large B-cell Lymphoma

Treatments studied

Part of Blood & lymphatic, Cancer clinical trials.

This study tests a new combination of targeted drugs and standard chemotherapy for a certain type of lymphoma. It aims to see if the new combination works better than the current standard treatment.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
128 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You have a type of lymphoma called double-expressor DLBCL, recently diagnosed.
  • You are between 18 and 65 years old.
  • You are physically active and able to care for yourself (ECOG score 0-2).
  • You have at least one tumor that can be measured on a scan.
  • Your heart, liver, kidneys, and blood counts are within normal limits.
  • You have not had previous treatment for this lymphoma.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07511114Not yet recruiting· Phase 3
Comparing two drug combinations for untreated double-hit lymphoma

This trial tests two different drug combinations to see which is better for people with a type of lymphoma that has certain genetic markers. It aims to improve outcomes for patients who have not received treatment before.

Shanghai
NCT06701357Recruiting· Phase 2
New drug combo for untreated aggressive lymphoma

This trial tests a new treatment combination for people newly diagnosed with a fast-growing type of lymphoma called diffuse large B-cell lymphoma (DLBCL) that has changes in two proteins, MYC and BCL2, making it a 'double expressor' lymphoma. The goal is to see if adding another drug to standard chemo-immunotherapy can improve results.

Shanghai, Shanghai Municipality
NCT06652152Not yet recruiting
Adding tucidinostat to standard chemo for double-expressor lymphoma

This trial compares two treatments for a certain type of aggressive lymphoma: the standard R-CHOP chemotherapy plus a study drug called tucidinostat (which may help fight cancer cells). The aim is to see if adding this drug helps patients with the double-expressor subtype do better.

NCT07415980Not yet recruiting· Phase 1/Phase 2
Combination therapy for older adults with double-expressor lymphoma

This study tests a combination of three drugs (polatuzumab vedotin, rituximab, and chidamide) for older adults newly diagnosed with a certain type of aggressive lymphoma called double-expressor DLBCL. The goal is to see if this combination is safe and effective for people who may not be able to handle standard, more intense chemotherapy.

NCT06977711Recruiting· Phase 1
Testing a new drug combo for high-risk DLBCL

This trial is testing a new combination of drugs for people with a high-risk type of lymphoma called DLBCL who have not been treated before. It adds loncastuximab and roflumilast to the standard R-CHOP therapy to see if it works better at fighting the cancer.

San Antonio, Texas
NCT07397832Recruiting· Phase 2
CRP drug combo for older adults with untreated double-positive DLBCL

This trial tests a new combination of drugs (CRP regimen) for older patients who have not yet been treated for a specific type of DLBCL called double-expressor lymphoma. It aims to see if this combination is effective and safe for people who may not be able to get standard chemotherapy.

Tianjin, Tianjin Municipality

Hear when a new BTK Inhibitors trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.