Personalized T cell therapy for blood cancers
Treatments studied
Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.
This trial tests a treatment that takes your own immune cells, modifies them to attack cancer cells, and gives them back to you. It is for people with certain blood cancers who have specific gene changes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have one of these blood cancers: acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML), chronic myeloid leukemia (CML), T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), or multiple myeloma.
- Your cancer must have a specific gene change (in TP53 or RAS) and you must have a specific tissue type (HLA type) that matches the treatment target.
- You must have already tried standard treatments for your cancer, and either cannot have a stem cell transplant or have chosen not to have one (for some cancers).
- You must be at least 18 years old and have a good level of daily activity (ECOG 0 or 1).
- You must be willing to stay near the treatment center for at least 2 weeks after the T cell infusion and to undergo required tests and procedures, including bone marrow biopsies.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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