A new pill for depression when current treatment isn't working well enough
Treatments studied
Part of Mental health clinical trials.
This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a diagnosis of major depressive disorder or persistent depressive disorder.
- Your current antidepressant hasn't worked well enough for this episode of depression.
- You have been taking an oral antidepressant for at least 8 weeks and can stay on the same dose for the study.
- You have a high depression severity score (≥22 on the Hamilton Depression Rating Scale).
- You do not have other primary psychiatric conditions (like bipolar disorder) that were the main focus of treatment in the last year.
- You are not at immediate risk of self-harm or suicide, and your depression has not previously failed to respond to electroconvulsive therapy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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