Adding pioglitazone to SGLT2 inhibitor for type 1 diabetes
Treatments studied
Part of Hormones & metabolism, Immune system & allergy clinical trials.
This trial tests if adding pioglitazone to an SGLT2 inhibitor can lower blood sugar more and prevent high ketone levels in people with type 1 diabetes. It may help those who have poor blood sugar control despite insulin therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older with type 1 diabetes.
- Your blood sugar is not well controlled (HbA1c between 7.0% and 11.0%).
- You take insulin through multiple daily injections or an insulin pump, and your total daily dose is at least 0.6 units per kilogram of body weight.
- Your insulin dose has been stable (within 4 units per day) for the past 3 months.
- Your kidney function is good (eGFR 60 or higher).
- Your weight has not changed by more than 3 pounds in the last 3 months, and you do not do very heavy exercise.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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