Treatment
Pioglitazone clinical trials
We’re tracking 26 recruiting studies that include Pioglitazone, each written for real people, not researchers, below.
Recruiting studies
- NCT07053319RecruitingPhase 1
Study of diabetes drugs and ketones
This trial tests how combining a ketone supplement with certain diabetes medicines affects blood sugar and ketone levels. It may help adults with type 2 diabetes who are not on insulin or certain other drugs.
San Antonio, TexasAges 30–75 - NCT05013255RecruitingPhase 2
Pioglitazone to treat fatigue in hormone-positive breast cancer
This Phase 2 study tests whether pioglitazone can reduce fatigue in people with certain types of breast cancer. You may be eligible if your cancer is estrogen- and progesterone-positive (ER+/PR+) and you plan surgery soon.
Morgantown, West VirginiaAges 18 years+ - NCT06989723RecruitingPhase 4
Pioglitazone and empagliflozin for fatty liver in type 2 diabetes
This trial tests two diabetes pills (pioglitazone and empagliflozin) to see if they can reduce liver fat in people with type 2 diabetes and fatty liver disease. It may help if your diabetes is not well controlled and you have a fatty liver confirmed by a special ultrasound scan.
Seongnam-siAges 20 years+ - NCT05946564RecruitingPhase 3
Pioglitazone to protect kidney function in ANCA vasculitis
This Phase 3 trial tests whether pioglitazone can help protect kidney function in people with newly diagnosed or relapsing ANCA-associated vasculitis that is actively affecting the kidneys. It aims to improve “renal tolerance,” meaning your kidneys may be better able to tolerate the disease and treatment.
AmiensAges 18–80 - NCT05838287RecruitingPhase 4
Pioglitazone for heart failure with preserved pumping in type 2 diabetes
This trial tests whether pioglitazone (a diabetes medicine) helps people who have type 2 diabetes and a specific type of heart failure where the heart pumps normally. It may improve heart failure symptoms and function in carefully selected patients.
San Antonio, TexasAges 30–70 - NCT07056699RecruitingPhase 3
Study on diabetes drugs and ketone production in type 1 diabetes
This trial tests how two diabetes medications, SGLT2i and pioglitazone, affect ketone production in people with type 1 diabetes. It aims to find new ways to improve blood sugar control.
San Antonio, TexasAges 18 years+ - NCT07462065RecruitingPhase 4
Clomiphene with or without Pioglitazone for PCOS
This study compares two fertility treatments: clomiphene alone or clomiphene plus pioglitazone. It aims to see if adding pioglitazone improves ovarian stimulation in women with PCOS.
Islamabad, FederalAges 18–38 - NCT06729996RecruitingPhase 2
Comparing two diabetes medicines for pancreatitis-related diabetes
This trial tests whether pioglitazone or empagliflozin is better at managing diabetes caused by chronic or recurrent pancreatitis. You will take one of these pills daily for 6 months and track your blood sugar and ketones at home. The goal is to find a safer, more effective treatment for this type of diabetes.
Rochester, MinnesotaAges 18–80 - NCT05727761RecruitingPhase 2
Pioglitazone plus metformin for high-risk mouth lesions
This trial studies whether a two-medicine diabetes drug combination can reduce or control risky early changes in certain mouth and throat lesions. You may be asked for small tissue samples (biopsies) before and after 12 weeks to see how the lesions respond.
Minneapolis, MinnesotaAges 18 years+ - NCT04501406RecruitingPhase 2
Low-dose pioglitazone for fatty liver disease in people with type 2 diabetes
This Phase 2 study tests whether low-dose pioglitazone can improve NASH, a type of fatty liver disease, in adults who also have type 2 diabetes. You may be able to join if your diabetes medicines and lab tests meet specific safety and stability requirements.
Gainesville, FloridaAges 21–75 - NCT05028140RecruitingPhase 3
Testing a lifestyle-and-diet program for type 2 diabetes control
This Phase 3 study tests whether a program run by the Piemonte Association can improve blood sugar control in people with type 2 diabetes who haven’t reached their target after usual diet, exercise, and stable medicines. It also aims to check that the approach is safe for participants.
Hortolândia, São PauloAges 18–85 - NCT05753657RecruitingEarly Phase 1
Testing insulin and blood sugar monitoring with pioglitazone
This early study tests whether adding pioglitazone, along with close blood-sugar (glucose/insulin) monitoring, can help control high insulin and high blood sugar in people starting alpelisib for metastatic breast cancer. It may help reduce blood-sugar side effects from alpelisib.
HaifaAges 18–85 - NCT06336798RecruitingPhase 2
Pioglitazone for pulmonary hypertension from lung disease
This trial tests if pioglitazone, a medicine used for diabetes, can help people with high blood pressure in their lungs caused by chronic lung disease. The goal is to see if it improves how your cells use energy.
Atlanta, GeorgiaAges 18 years+ - NCT06399835RecruitingPhase 4
Comparing two diabetes drugs for blood sugar and heart health
This study tests a new diabetes medicine called Enavogliflozin against an older drug, Pioglitazone, to see which works better for lowering blood sugar and improving heart health. If you have type 2 diabetes, take metformin plus another pill, and your A1C is between 7 and 10.5, this study may be an option for you.
Seongnam-si, Gyeonggi-doAges 20–80 - NCT06657209RecruitingPhase 4
Comparing diabetes treatments for people with normal weight
This study tests two medications—pioglitazone (a pill) and tirzepatide (an injection)—in people with type 2 diabetes who have a normal body weight. It aims to find which treatment works better for this specific group.
Palo Alto, CaliforniaAges 30–70 - NCT02889003RecruitingPhase 2
Second attempt to stop treatment after pioglitazone in CML
This trial tests if a short course of pioglitazone (a diabetes drug) before stopping your TKI therapy can help you stay in remission longer. It is for people with chronic myeloid leukemia (CML) who have already lost their remission after a first or later attempt to stop TKI treatment.
Le ChesnayAges 18 years+ - NCT05305287RecruitingPhase 4
Measuring liver energy use in people with diabetes and fatty liver disease
This study looks at how the liver uses energy (mitochondria) in people with type 2 diabetes and fatty liver disease. By understanding this, researchers may find better ways to treat liver problems.
San Antonio, TexasAges 18–80 - NCT06875193RecruitingPhase 4
Comparing dapagliflozin vs pioglitazone for type 2 diabetes
This study is testing two different diabetes pills—dapagliflozin or pioglitazone—in people with type 2 diabetes. The goal is to see which one works better when added to your current metformin and DPP-4 inhibitor. You may qualify if your blood sugar is not well controlled with your current medications.
SeoulAges 19 years+ - NCT02969798Recruiting
Study of prediabetes with abnormal sugars and medicines
This study looks at adults with prediabetes—specifically abnormal fasting and/or 2-hour blood sugar tests—to see whether a treatment helps improve sugar control. You may also be compared with people who have normal blood sugar (the control group).
San Antonio, TexasAges 18–65 - NCT03866408RecruitingEarly Phase 1
Testing how insulin affects fat breakdown proteins
This early study looks at how insulin changes the body’s fat breakdown and related proteins. You might join if you’re within a certain body-weight range and can safely take the study medication.
Rochester, MinnesotaAges 18–55 - NCT07117630RecruitingPhase 2
A new drug combo for advanced breast cancer after standard treatment
This trial tests a new drug combination for women with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has worsened after standard treatments like CDK4/6 inhibitors and hormone therapy. It aims to see if the combination can help when other options have stopped working.
ShanghaiAges 18 years+ - NCT05501483Recruiting
Study how fat differences may relate to type 2 diabetes
This study looks at differences in body fat to understand why some people develop type 2 diabetes. You may be asked for blood tests and health information to see if your diabetes risk and body fat patterns are linked.
StockholmAges 30–70 - NCT06246799RecruitingPhase 3
Comparing two pill combinations for new diabetes
This study compares two different two-drug combinations for people recently diagnosed with type 2 diabetes. It aims to find which combination works better to control blood sugar and improve overall health.
San Antonio, TexasAges 18–75 - NCT07083388RecruitingPhase 1
Study of how different forms of BR3006 work in healthy adults
This trial tests how the body processes different forms of a drug called BR3006 in healthy volunteers. It compares a single tablet (BR3006) to a combination of three separate components (BR3006A, BR3006B, and BR3006C) given together. This helps researchers understand if the combination works the same as the single tablet.
Seoul, Gwanak-guAges 19 years+
What Pioglitazone is being studied for
Conditions with recruiting Pioglitazone studies.
Common questions
- Are there clinical trials studying Pioglitazone?
- Yes. Clin2 currently lists 26 recruiting studies that include Pioglitazone, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Pioglitazone trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Pioglitazone an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Pioglitazone or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.