CADASIL registry for confirmed patients and mutation carriers
Part of Brain & nervous system, Genetic & congenital, Heart & circulation clinical trials.
This study builds a group “registry” of people affected by CADASIL (a genetic brain blood-vessel condition) and people who carry the NOTCH3 mutation, even if they have no symptoms. It helps researchers learn more about the condition over time and compare experiences between patients, carriers, and healthy relatives or controls.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You can give informed consent (agree to join after understanding the study).
- You are older than 18 years.
- You have a confirmed CADASIL diagnosis, or you carry a NOTCH3 mutation, confirmed by genetic testing or skin biopsy.
- You are either a family member of someone with CADASIL, a NOTCH3 mutation carrier, or an unrelated healthy control.
- You can cooperate with the study team and follow study instructions.
- You do not have serious illness (like major heart, liver, kidney disease, or major mental illness) and you can safely do the imaging tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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