Tenecteplase for stroke treatment 24-72 hours after symptoms start
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests if the clot-busting drug tenecteplase can help people with a moderate to severe stroke when given 24 to 72 hours after symptoms began. It aims to see if this later treatment window can improve recovery and reduce disability.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older
- Your stroke symptoms started between 24 and 72 hours ago (or you were last seen well that long ago)
- You had little or no disability before the stroke (able to do daily activities independently)
- Your stroke is moderate to severe (NIHSS score 6-25, or 4-5 with a disabling symptom like vision loss or trouble speaking)
- Brain scans show a blocked artery and a mismatch between the area at risk and the already damaged area
- You are not at high risk of bleeding and have no recent major surgery, stroke, or bleeding issues
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether giving a clot-busting drug called tenecteplase directly into the brain's blood vessels can help complete the removal of a clot after a first attempt at mechanical extraction was only partially successful.
This trial tests a specialized clot-removal treatment for people who had a mild but disabling stroke up to 24 hours ago and have a large artery blockage in the brain. The goal is to see if this precision therapy can help reduce disability and improve recovery.
This registry tracks how well tenecteplase (a clot-busting medication) works when given more than 4.5 hours after a stroke starts. Researchers want to learn if treating strokes this late can still help patients recover.
This trial tests a clot-busting drug called tenecteplase for patients having a mild stroke (with weakness on one side or trouble speaking) who can get treatment within 4.5 hours. The goal is to see if this drug helps improve blood flow and reduces disability.
This trial tests a clot-busting drug called tenecteplase given directly into the brain artery for people having a moderate stroke caused by a blockage in a medium-sized blood vessel. The goal is to see if it helps improve recovery when given within 24 hours of stroke symptoms starting.
This study tests a medication called tenecteplase, given before a procedure to remove a large blood clot in the brain. It may help people who have had a severe stroke within the last 4.5 hours.
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