Testing tenecteplase after incomplete clot removal for stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether giving a clot-busting medication (tenecteplase) directly into the artery after an incomplete clot-removal procedure can improve blood flow and outcomes in people with large vessel strokes. It aims to help those who had partial reopening after mechanical thrombectomy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your stroke symptoms started within the last 24 hours.
- You have had a large vessel stroke in the front part of your brain (anterior circulation).
- You have already had a mechanical thrombectomy (a procedure to remove the clot) but the blood flow is not fully restored.
- You were independent before this stroke (able to care for yourself).
- You do not have conditions that increase bleeding risk or severe kidney problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a precise treatment to restore blood flow in people who had a mild but disabling stroke up to 24 hours earlier, using mechanical clot removal or clot-busting medication. The goal is to reduce long-term disability by reopening the blocked vessel while protecting healthy brain tissue.
This trial tests if the clot-busting drug tenecteplase can help people with a moderate to severe stroke when given 24 to 72 hours after symptoms began. It aims to see if this later treatment window can improve recovery and reduce disability.
This trial tests whether giving a clot-busting medication (tenecteplase) before the standard clot-removal procedure (thrombectomy) helps patients with a large stroke more than just the procedure alone. If the treatment works, it could improve recovery and reduce disability after a severe stroke.
This trial tests if giving a second dose of the clot-busting drug tenecteplase can help people whose stroke symptoms don't improve after the first dose, when a large or medium artery in the brain is still blocked. It may be an option for patients who cannot have a mechanical clot removal procedure.
This study tests a clot-dissolving drug called tenecteplase given directly into the artery after a mechanical thrombectomy (clot removal). The goal is to see if it helps improve blood flow to the small vessels in the brain after the main clot is removed.
This trial tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after a successful mechanical clot removal can improve recovery for people with a certain type of stroke. The goal is to see if it safely helps clear any remaining tiny clots and reduces disability.
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