Study of Calderasib with other drugs for colorectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a new drug called Calderasib combined with targeted therapy or chemotherapy for people with advanced colorectal cancer that has a specific genetic change (KRAS G12C mutation). It may be an option for those who have not had prior treatment for advanced disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced colorectal cancer (stage 3 or 4) that cannot be removed by surgery.
- Your tumor has a specific genetic change called KRAS G12C mutation.
- You have not had cancer treatment for advanced disease before (except a short course of FOLFOX or CAPOX chemotherapy).
- If you have HIV, it must be well controlled with medication.
- If you have hepatitis B or C, the virus must be undetectable with treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests a new combination of drugs (sotorasib, panitumumab, and FOLFIRI) against the standard treatment for colorectal cancer that has spread. It's for people whose tumor has a specific KRAS G12C mutation and who have not had chemotherapy before for advanced disease.
This trial tests an experimental drug (BAY 3771249) for people with advanced or metastatic colorectal cancer that has a specific genetic change called KRAS G12D. The goal is to see if the drug is safe and if it can help shrink tumors.
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