Clin2
NCT07002177Possibly a fitRecruiting

Combination therapy study for ER+/HER2- breast cancer

Metastatic Breast CancerBreast Cancer Stage IBreast Cancer Stage IILocally Advanced Breast Cancer (LABC)ER+ Breast Cancer

Treatments studied

Part of Cancer, Skin clinical trials.

This trial tests a new drug called FWD1802 combined with other treatments for people with a certain type of advanced breast cancer (ER-positive, HER2-negative). It aims to find better options if standard treatments have stopped working or aren't suitable.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
196 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • Your breast cancer must be ER-positive and HER2-negative (confirmed by a biopsy).
  • Your cancer has spread or come back in a different part of the body (advanced or metastatic).
  • You have tried at least one hormone therapy that stopped working, or your cancer returned within 1 year of finishing 2+ years of hormone therapy.
  • You have had no more than 2 prior chemotherapy treatments for advanced disease.
  • You have not used a type of drug called a SERD (except fulvestrant).
  • You must have at least one tumor that can be measured or seen on a scan.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06064812Recruiting· Phase 1/Phase 2
Testing a new drug for advanced ER-positive breast cancer

This trial tests an experimental oral drug (FWD1802) for women with a specific type of advanced breast cancer (ER-positive, HER2-negative) that has stopped responding to hormone therapy. It looks at whether the drug can slow or stop cancer growth, especially if you have an ESR1 mutation.

Hefei, Anhui
NCT05696626Recruiting· Phase 3
Test a new pill plus abemaciclib versus standard therapy

This Phase 3 study compares lasofoxifene plus abemaciclib versus fulvestrant plus abemaciclib for ER-positive, HER2-negative breast cancer that has an ESR1 mutation. It looks for better tumor control in people whose cancer has progressed on hormone therapy (an aromatase inhibitor) and who meet specific safety and testing requirements.

Scottsdale, Arizona
NCT05524584Recruiting· Phase 2
Anastrozole, fulvestrant, and abemaciclib for hormone-positive breast cancer

This trial tests whether combining three medicines can better control hormone-receptor–positive, HER2-negative metastatic breast cancer that cannot be cured with surgery or radiation. It may help shrink tumors and slow disease growth compared with standard hormone therapy approaches.

Orange, California
NCT06856200Recruiting
Sirolimus plus palbociclib and fulvestrant for advanced breast cancer

This trial tests a new combination of three drugs (sirolimus, palbociclib, and fulvestrant) for people with a certain type of advanced breast cancer that is hormone receptor-positive and HER2-negative. The goal is to see if adding sirolimus can help control the cancer when standard hormone therapy is no longer working.

Shanghai
NCT05608252Recruiting· Phase 1/Phase 2
Drug combination for advanced ER-positive, HER2-negative breast cancer

This Phase 1/2 study tests how well a new treatment combination (VS-6766, abemaciclib, and fulvestrant) works for metastatic or hard-to-remove breast cancer that is hormone-driven (ER/PR positive) and HER2 negative. It is mainly designed to find the safest dose and then see whether it can control the cancer after it has progressed on certain prior medicines.

Boston, Massachusetts
NCT04802759Recruiting· Phase 1/Phase 2
Testing drug combinations for recurrent or advanced ER-positive breast cancer

This early-phase trial tests several combinations of cancer medicines to slow or control ER-positive breast cancer that has returned or progressed. It also checks safety and whether tumor or blood biomarkers can help match the right treatment to the right person.

Duarte, California

Hear when a new Metastatic Breast Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.