Closed-loop pump vs islet transplant for unstable type 1 diabetes
Part of Hormones & metabolism, Immune system & allergy clinical trials.
This study compares two advanced treatments for type 1 diabetes that is hard to control: a closed-loop insulin pump system (which automatically adjusts insulin) versus islet cell transplantation (which replaces the cells that make insulin). It is for people whose blood sugar stays very unstable despite using the best current therapies.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have type 1 diabetes with large and unpredictable blood sugar swings that have lasted for more than a year.
- Your blood sugar swings are causing serious problems, like frequent severe low blood sugar events (needing help from others) or dangerous highs (ketoacidosis).
- You have tried and are using modern diabetes tools (insulin pump, continuous glucose monitor, and a diabetes team) but still have unstable blood sugar.
- You are not currently using a closed-loop insulin pump system.
- You have not had a kidney transplant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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