Thyroid hormone for lack of motivation in schizophrenia
Part of Mental health clinical trials.
This trial tests whether adding a thyroid hormone (thyroxine) to your current antipsychotic medication can improve low motivation and drive, which are common in schizophrenia. It aims to see if this addition is safe and helpful for people who are otherwise stable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 45 years old and right-handed.
- You have a diagnosis of schizophrenia and are currently stable, with your main antipsychotic dose unchanged for at least 4 weeks.
- You have significant lack of motivation, but only mild positive symptoms (like hallucinations or delusions).
- You are taking one or two second-generation antipsychotics (like risperidone, olanzapine, etc.) and can keep the same dose during the trial.
- You do not take clozapine or older antipsychotics, and you have no thyroid problems or heart conditions.
- You are not pregnant, planning pregnancy, or breastfeeding, and you have no metal implants or claustrophobia (since MRI is involved).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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