T4/T3 combination therapy for hypothyroidism symptoms
Treatments studied
Part of Hormones & metabolism clinical trials.
This trial tests if adding a second thyroid hormone (T3) to standard levothyroxine (T4) can better relieve persistent hypothyroidism symptoms like fatigue or brain fog. You may qualify if you still have symptoms despite being on a stable dose of levothyroxine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have had hypothyroidism (from thyroid removal or thyroid failure) for at least 6 months.
- You are currently taking levothyroxine (T4) at a dose between 75-150 mcg per day and at least 1.2 mcg per kilogram of body weight, and have been on the same dose for at least 3 months.
- Your TSH level was between 0.5 and 4.0 mU/L in the last 2 months.
- You have had ongoing hypothyroid symptoms (like fatigue, weight gain, depression) for at least 2 months and scored 5 or more on a symptom questionnaire.
- You are not using certain medications such as T3, amiodarone, lithium, or biotin, and you have no serious heart problems or uncontrolled psychiatric conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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