Combination therapy for STK11-mutant lung cancer
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a new drug (GT103) combined with the approved immunotherapy drug pembrolizumab for people with advanced lung cancer that has a specific genetic change (STK11). The goal is to see if adding GT103 helps control the cancer better than pembrolizumab alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- Your lung cancer must have a change in the STK11 gene, confirmed by a genetic test.
- Your cancer must have grown while you were on a checkpoint inhibitor like pembrolizumab, and your doctor thinks you can continue it.
- You should be physically able to take care of yourself (a score of 0 or 1 on a common activity scale).
- You must have measurable disease on scans (at least one tumor that can be seen and measured).
- You need adequate organ function (kidney, liver, blood counts) and a healthy heart (measured by an echocardiogram or similar).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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