Can a special PET scan improve surgery for primary aldosteronism?
Part of Cancer, Hormones & metabolism clinical trials.
This study uses a new type of PET scan (called Gallium-68 Pentixafor PET-CT) to help doctors better identify the source of a hormone problem causing high blood pressure. The goal is to see if this scan leads to better surgical outcomes compared to standard methods.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 19 years or older.
- You have been diagnosed with primary aldosteronism (a condition where your adrenal glands make too much of the hormone aldosterone, causing high blood pressure).
- You have already had a CT scan of your adrenal glands.
- You are willing to sign a consent form to participate.
- You are not pregnant, breastfeeding, or planning to become pregnant.
- You are willing to consider surgery as a treatment option.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a special PET scan (using a tracer called PentixaFor) to see if it can help find which adrenal gland is making too much aldosterone in people with primary aldosteronism. The goal is to reduce the need for more invasive tests like adrenal vein sampling.
This study compares a newer, less invasive PET/CT scan (using 68Ga-Pentixafor) to the standard adrenal vein sampling test to identify which adrenal gland is causing high blood pressure in people with primary aldosteronism. If you're considering surgery to remove a nodule on your adrenal gland, this trial may help determine the best approach.
This trial tests a special PET scan (68Ga-Pentixafor) to see if it can replace a more invasive blood test (AVS) for finding which adrenal gland is causing high blood pressure and high cortisol levels. It may help patients avoid a complicated procedure.
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This trial tests a new imaging method called [18F]CETO PET scan to better understand the cause of high blood pressure due to primary aldosteronism (PA). It may help guide treatment decisions without needing more invasive tests.
This study tests two new types of PET/MR scans (68Ga-Pentixafor and 68Ga-FAPI-04) to see if they can better detect the cause of primary aldosteronism — a condition that leads to hard-to-control high blood pressure. The scans may help doctors decide which treatment is best for you.
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