Using genetics to personalize valproate treatment for epilepsy
Part of Brain & nervous system clinical trials.
This trial studies how a person's genes affect their response to the epilepsy drug valproate. The goal is to find the best dose for each patient to improve seizure control and reduce side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have epilepsy (either primary or secondary) and your medical records are complete.
- You have been taking valproate regularly for at least 5 days, and your blood levels are stable.
- You take valproate either alone or with other anti-seizure medications.
- You do not have serious liver or kidney problems, and you are not pregnant.
- You are 65 years old or younger.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies whether adding a medicine called lamotrigine to valproate reduces seizures in children who haven’t fully stopped having seizures yet. It will also watch safety with lab tests and the child’s overall response.
This study aims to find genetic causes of epilepsy and use that information to personalize your care. It involves analyzing your DNA to look for gene changes that may be linked to your seizures.
This trial uses detailed brain tests to better match people with epilepsy to the right treatment. It may help by using “precision medicine” methods to understand what in the brain is driving seizures.
This study checks whether genetic markers are linked to heart rhythm problems in people with epilepsy or seizure-related events, and in some close relatives. It may help doctors better spot who is at risk for dangerous heart rhythm issues.
This study tests a personalized, non-invasive brain stimulation method called tDCS for people with drug-resistant epilepsy that starts in one part of the brain. It aims to reduce seizures in those who cannot have surgery or have not been helped by surgery.
This trial tests a personalized brain stimulation method (transcranial electrical stimulation) to reduce seizures in children with hard-to-control partial epilepsy. It aims to find the best stimulation spot and settings for each patient by using advanced brain scans.
Hear when a new Epilepsy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.