Testing NT-I7 after CAR T-cell therapy for large B-cell lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests whether a drug called NT-I7 (efineptakin alfa) can help people with large B-cell lymphoma who have already received a CAR T-cell treatment like Yescarta or Breyanzi. It aims to boost your immune system's recovery and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have large B-cell lymphoma that has come back or not responded to previous treatment.
- You must have measurable disease on a PET/CT scan.
- You must be eligible to receive a standard CAR T-cell therapy (Yescarta or Breyanzi) as part of your treatment.
- You must be at least 18 years old.
- You must have adequate organ and bone marrow function, such as certain blood cell counts and kidney function.
- You cannot have active central nervous system involvement from lymphoma, uncontrolled heart disease, or certain autoimmune conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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